LSU Health New Orleans

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Administration Basic Sciences Clinical Sciences Centers of Excellence

 

Byoung  S.  Kwon , Ph.D.

Professor of Ophthalmology

LSU Eye Center
2020 Gravier St. Suite B
New Orleans, LA 70112
Phone (office): (504) 568-2413
Phone (Lab): (504) 568-2553
Fax: (504) 568-2385
Email: bkwon@lsuhsc.edu

Research Interests Immunology
Selected Publications

Asai T, Choi BK, Kim WY, Kim JD, Vinay DS, Gebhardt BM, Kwon BS: Blockade of the 4-1BB(CD137)/4-1BBL, LFA-1/ICA01, and/or CD28/CD80-86 costimulatory pathways promote differential corneal allograft survival in mice. Immunology 121:349-358, 2007. PM:17376197 

Bae EM, Kim WJ, Suk K, Kang YM, Park JE, Kim WY, Choi EM, Choi BK, Kwon BS, Lee WH: Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages. Mol Immunol 45:523-533, 2007. PM:17602748 

Choi BK, Kim YH, Kang WJ, Lee SK, Kim KH, Shin SM, Yokoyama WM, Kim TY, Kwon BS : Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res 67:8891-8899, 2007. PM:17875731 

Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J: Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nature Immunol 8:601-609, 2007. PM:17496895 

Lee SJ, Rossi RJ, Lee SK, Croft M, Kwon BS, Mittler RS, Vella AT: CD134 costimulation couples the CD137 pathway to induce production of supereffector CD8 T cells that become IL-7 dependent. J Immunol 179:2203-2214, 2007. PM:17675480 

Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D, Spencer T, Dillehay D, Kwon BS, Chen L, Vella AT, Mittler RS: Cytokine-mediated disruption of lymphocyte trafficking, hematopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137 treated mice. J Immunol 178:4194-4213, 2007. PM:17371976 

Rudolf D, Silberzahn T, Walter S, Maurer D, Engelhard J, Wernet D, Buhring HJ, Jung G, Kwon BS, Rammensee HG, Stevanovic S: Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells. Cancer Immunol Immunother  July 27, 2007 – Epub ahead of print. PM:17657490 

Shin S, Kim YH, Choi BK, Kwon BS: 4-1BB triggers IL-13 production through a distinct signaling pathway in T lymphocytes. J Leukoc Biol 81:1455-1465, 2007. PM:17389581 

Shin YH, Lee GW, Son KN, Lee SM, Kang CJ, Kwon BS, Kim J. Promoter analysis of human CC chemokine CCL23 gene in U937 monocytoid cells. Biochim Biophys Acta 1769:204-208, 2007. PM:17368823 

Vinay DS, Choi JH, Kim JD, Choi BK, Kwon BS: Role of endogenous 4-1BB in the development of systemic lupus erythematosus. Immunology 122:394-400, 2007. PM:17608689 

Vinay DS, Kim JD, Asai T, Choi BK, Kwon BS: Absence of 4 1BB gene function exacerbates lacrimal gland inflammation in autoimmune-prone MRL-Faslpr mice. Invest Ophthalmol Vis Sci 48:4608-4615, 2007. PM:17898284 

Zhang B, Maris CH, Foell J, Whitmire J, Niu L, Song J, Kwon BS, Vella AT, Ahmed R, Jacob J, Mittler RS: Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117:3029-3041, 2007. PM:17853940