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Administration Basic Sciences Clinical Sciences Centers of Excellence

 

Bryan  M.  Gebhardt , Ph.D.

Emeritus Professor of Ophthalmology and Microbiology

LSU Eye Center
2020 Gravier St. Suite B
New Orleans, LA 70112
Phone (office): (504) 568-2809
Phone (Lab): 
Fax: (504) 568-2385
Email: bgebha@lsuhsc.edu

Immunology Laboratory

Research Interests Immunology
Selected Publications

Si Z, Palkama A, Gebhardt BM, Velasquez D, Galeano MJ, Beuerman RW: Distribution of thrombospondin-4 in the bovine eye. Curr Eye Res 27(3):165 173, 2003. PM:14562182

Halford WP, Balliet JW, Gebhardt BM: Re-evaluating natural resistance to herpes simplex virus type 1. J Virol 78:10086-10095, 2004. PM:15331741

Gebhardt BM, Varnell ED, Kaufman HE: Acetylsalicylic acid reduces viral shedding induced by thermal stress. Curr Eye Res 29:119-125, 2004. PM:15512958

Gebhardt BM, Kaufman HE, Hill JM: Effect of acyclovir on thermal stress-induced herpesvirus reactivation. Curr Eye Res 29:137-144, 2004. PM:15512960

Jung HW, Jung CR, Choi BM, Vinay DS, Hill JM, Gebhardt BM, Kwon BS: Herpesvirus infection of ICAM-1 deficient mice. Curr Eye Res 29:201-208, 2004. PM:15512968

Vinay DA, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS: CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to LPS-induced shock syndromes, and have lower IL-4 responses. J Immunol 173:4218 4229, 2004. PM:15356173

Hill JM, Gebhardt BM, Azcuy AM, Matthews KE, Lukiw WJ, Steiner I, Thompson HW, Ball MJ: Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease? Med Hypotheses 64:320-327, 2005. PM:15607565

Jacob JT, Rochefort JR, Bi JJ, Gebhardt BM: Corneal epithelial cell growth over tethered-protein/peptide surface-modified hydrogels. J Biomed Mater Res: Part B-Applied Biomaterials 72:198-205, 2005. PM:15486971

Gebhardt BM, Varnell ED, Kaufman HE: Inhibition of cyclooxygenase 2 synthesis suppresses Herpes simplex virus type 1 reactivation. J Ocul Pharmacol Ther 21:114-120, 2005. PM:15857277

Manikowski A, Verri A, Lossani A, Gebhardt BM, Gambino J, Focher F, Spadari S, Wright GE: Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem 48:3919-3929, 2005. PM:15916444

Halford WP, Maender JL, Gebhardt BM: Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1. Virol J 2:56, 2005. PM:16022737

Gebhardt BM, Halford WP: Evidence that spontaneous reactivation of herpes virus does not occur in mice. Virol J 2:67, 2005. PM:16109179

Halford WP, Weisend C, Grace J, Soboleski M, Carr DJ, Balliet JW, Imai Y, Margolis TP, Gebhardt BM: ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J 3:44, 2006. PM:16764725

Asai T, Choi BK, Kwon PM, Kim WY, Kim JD, Vinay DS, Gebhardt BM, Kwon BS: Blockade of the 4 1BB (CD137)/4 1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice. Immunology 121:349-358, 2007. PM:17376197

Kaufman HE, Varnell ED, Gebhardt BM, Thompson HW, Atwal E, Rubsamen-Waigmann H, Kleymann G: Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection. J Ocular Pharmacol Therapeutics, 2007, in press.

Wright GE, Wright GE, Gebhardt BM, Manikowski A, Focher F: Combination therapy of experimental herpes simplex encephalitis, Antiviral Res, Submitted, 2007.